September, 16 -18
| Monday, September 16 | |
| 08:30 – 09:00 | Registration |
| 09:00 – 09:10 | Welcome remarks from the organizing team |
| 09:10 - 09:40 | Susana M. Cerritelli: Role of RNase H1 in the nucleus: Past and present insights. |
| 09:40 - 10:05 | Frédéric Chédin: Manipulating RNase H1 levels in murine B cells dramatically affects mitochondrial genome maintenance but shows little impact on nuclear R-loop distributions. |
| 10:05 - 10:30 | Sheetal Uppal: RNase H1 contributes to alternative splicing regulation. |
| 10:30 – 11:00 | Coffee Break |
| 11:00 – 11:25 | Hai Dang Nguyen: RNase H1 phosphorylation at Ser76 promotes RPA interaction to safeguard genome integrity from R-loop- associated instability. |
| 11:25 – 11:50 | Petra Beli: Regulation of human RNase H1 by phosphorylation. |
| 11:50 – 12:15 | Marcin Nowotny: Mechanism of the RNase H domain of reverse transcriptases. |
| 12:15 – 12:40 | Robert J Crouch: Chaos leading to survival after loss of RNase HI and RecBCD in E. coli. |
| 12:40 – 14:00 | lunch |
| 14:00 – 14:25 | Andrei Kuzminov: UV-induced Replication-Transcription Conflicts. |
| 14:25 – 14:50 | Houra Merrikh: Regulation of replication restart from RNA:DNA. |
| 14:50 – 15:15 | Carolin Wagner: RNase H1 Prevents Transcription Replication Conflicts in the Absence of Sen1 in S. cerevisiae. |
| 15:15 – 15:40 | Vandit Shah: Investigate the potential role of RNase H1 in the development of chronic kidney disease. |
| 15:40 – 16:05 | Natalia Gromak: Toxic R-loops in Repeat Expansion Diseases. |
| 16:05 – 17:00 | Coffe and poster session |
| 18:00 – ... | Dinner and get-together |
| Tuesday, September 17 | |
| 09:00 – 09:30 | Jessica Williams: High fidelity DNA ligation is critical for preventing genome instability. |
| 09:30 – 09:55 | Percy P. Tumbale: Molecular basis for RNA discrimination by human DNA ligase 1. |
| 09:55 – 10:20 | Paulina H. Wanrooij: Ribonucleotide removal pathways in mammalian mitochondria: the poor endoribonuclease activity of human mitochondrial topoisomerase protects against rNMP-dependent deletions. |
| 10:20 – 10:45 | Andrei Chabes: Impact of dNTP/rNTP Ratios on Ribonucleotide Incorporation into mtDNA. |
| 10:45 – 11:15 | Coffee Break |
| 11:15 – 11:40 | Kristi L. Jensen: Genomic ribonucleotide metabolism contributes to replicative lifespan and is mis-regulated in aged yeast cells. |
| 11:40 – 12:05 | Diana Rios-Szwed: Synthetic lethality with RNase H2 and Ribonucleotide Excision Repair deficiency: new functions of EXO1 in mammalian DNA integrity. |
| 12:05 – 12:30 | Kiyoshi Yasukawa: Leu606 of human DNA polymerase δ plays a role in discriminating deoxyribonucleotide and ribonucleotide. |
| 12:30 – 12:55 | Maarten van den Ancker: Prediction of an evolutionary conserved complex between RNase H2 and Pol δ. |
| 12:55 – 14:30 | Lunch |
| 14:30 – 14:55 | Pablo Huertas: R-loops and interferon contribute to hamper homologous recombination in Aicardi-Goutières Syndrome. |
| 14:55 – 15:20 | Akira Sassa: Uncovering distinct DNA damage responses associated with RNase H2 deficiency and its pathogenic mutation in human TK6 cells. |
| 15:20 – 15:45 | Laura Hartleb: Initiation of DNA replication in Trypanosoma brucei is regulated by interaction of the RNase H2 complex with DOT1 histone methyltransferases. |
| 15:45 - 17:00 | Coffe Break |
| 17:30 - 19:00 | Social program (Wine Tasting) |
| 19:00 - ... | Dinner and get-together |
| Wednesday, September 18 | |
| 09:00 – 09:25 | Erik W. Debler: Non-Canonical mechanisms of RNase H2 recruitment to PCNA. |
| 09:25 – 09:50 | Philippe Pasero: Postreplicative RNA:DNA hybrids as a source of replication stress and inflammation. |
| 09:50 – 10:15 | Aziz El Hage: Genome-wide mapping of R-loops in cells deficient for the RNA exosome reveals enrichment of hybrids at sites of non-coding RNAs. |
| 10:15 – 10:50 | Coffee Break |
| 10:50 – 11:15 | Alex Bishop: Not all R-loops are equal. |
| 11:15 – 11:40 | Zicheng Yu: A machine-learning-based tool to detect DNA-embedded ribonucleotides from long-read nanopore sequencing. |
| 11:40 – 12:05 | Mo Sun: rNMPID: a database for ribonucleoside MonoPhosphates in DNA. |
| 12:05 – 12:20 | Closing remarks from the organizing team |
| 12:20 – 14:00 | Lunch and goodbye |
| 14:00 – 15:00 | Technical Talk with Alex Bishop: (open to everyone) Focus of the discussion: R-loop database RLBase, and peculiarities of R-loop mapping techniques. |